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Study shows interferon restriction decreases DNA damage and slows premature aging in mice.

by Published on 28th Apr 2015

by Published on 28th April 2015

Researchers from the University of Pennsylvania have pinpointed a molecular link between DNA damage, cellular senescence and premature aging.

During the study which focused on the chemical messenger interferon, a molecule that is naturally produced by the body in response to invading pathogens such as viruses, researchers discovered that interferon signaling increases in response to DNA damage and that this signaling prompts cells to enter senescence. However, when the researchers blocked the interferon signalling mice were able to not only live longer, but were more fertile, had less grey hair and were more active than regular mice.

While the study looked at premature aging and ways to alleviate it, it paves the way for future studies to mitigate the effects of normal aging in healthy individuals.

Read more at: Medical News Today