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by Valentina Lencautan Published on 16th Jun 2015
by Valentina Lencautan Published on 16th June 2015
recent study carried out by Ellen
Heber-Katz, PhD, of the Lankenau Institute for Medical Research
has demonstrated that spontaneous tissue regeneration can be achieved
in mice, without using additional stem cells. As reported in the
Science Translational Medicine, this is possible thanks to a form of
energy production present in mammals. The discovery of the central driver of healthy regeneration of lost tisse, the HIF-1, will offer opportunities to design therapies and treatments for healthy tissue regeneration in humans.
discovered that the oxygen regulatory HIF-1a pathway, employed also
in embryonic development, can activate a regrowth process of tissue
in mice, thus creating similar prospects for mammalian tissues. In
Dr. Heber-Katz' investigations MRL mice have shown to be quite an
exceptional species among the mammals for their ability to regenerate
cartilage and other types of tissues.
consisted of down-regulating HIF-1a in MRL mice who received an ear
hole punch, selecting a non regenerative strain and injecting a PHD
inhibitor into the mice. 30 days later researchers were able to
register ear healing and regrowth of cartilage and hair follicles.
to Dr. Heber-Katz the study “shows
the possibility of taking mature cells and, with addition of HIF-1a,
causing dedifferentiation to a highly immature state where the cells
can proliferate, followed by redifferentiation upon withdrawal of
HIF-1a".Read more @ Medicalxpress